The mode of action of antimalarial endoperoxides
نویسندگان
چکیده
منابع مشابه
The mode of action of antimalarial endoperoxides.
The mechanism of action of artemisinin appears to involve two steps. In the first step, activation, intra-parasitic iron catalyses the cleavage of the endoperoxide bridge and the generation of free radicals. In the second step, alkylation, the artemisinin-derived free radical forms covalent bonds with parasite proteins.
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چکیده ندارد.
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ژورنال
عنوان ژورنال: Transactions of the Royal Society of Tropical Medicine and Hygiene
سال: 1994
ISSN: 0035-9203
DOI: 10.1016/0035-9203(94)90468-5